JX-970 is also derived from a Western Reserve strain vaccinia virus. In addition, it expresses GM-CSF to stimulate immune reponses. in preclinical studies, the JX-970 backbone exerted a tumor debulking effect and at the same time demonstrated a selective preference for tumor tissues.1
• JX-900 is a series of modified vaccinia vaccine (Western Reserve strain) with enhanced oncolytic potency
• Attenuation via “Double-Deletion” : TK (thymidine kinase) & VGF (vaccinia growth factor) gene inactivation.